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math.ST2009★ 13 cited
Estimating the Gumbel scale parameter for local alignment of random sequences by importance sampling with stopping times
Yonil Park, Sergey Sheetlin, John L. Spouge
The gapped local alignment score of two random sequences follows a Gumbel distribution. If computers could estimate the parameters of the Gumbel distribution within one second, the…
q-bio.GN2009
Exceptional error minimization in putative primordial genetic codes
Artem S. Novozhilov, Eugene V. Koonin
We investigated the error-minimization properties of putative primordial codes that consisted of 16 supercodons, with the third base being completely redundant, using a previously…