output
20072023
most citedA general framework for modeling tumor-immune system competition and immunotherapy: mathematical analysis and biomedical inferences

296 citations

16 papers

cs.RO2023★ 17 cited

Towards Safer Robot-Assisted Surgery: A Markerless Augmented Reality Framework

Ziyang Chen, Laura Cruciani, Ke Fan +6

Robot-assisted surgery is rapidly developing in the medical field, and the integration of augmented reality shows the potential of improving the surgeons' operation performance by…

q-bio.BM2023★ 4 cited

Locality of contacts determines the subdiffusion exponents in polymeric models of chromatin

E. Marchi, Y. Zhan, G. Tiana

Loop extrusion by motor proteins mediates the attractive interactions in chromatin on the length scale of megabases, providing the polymer with a well-defined structure and at the…

physics.med-ph2022★ 161 cited

Dosimetric commissioning and quality assurance of scanned ion beams at the Italian National Center for Oncological Hadrontherapy

Alfredo Mirandola, S. Molinelli, G. Vilches Freixas +9

Purpose: To describe the dosimetric commissioning and quality assurance (QA) of the actively scanned proton and carbon ion beams at the Italian National Center for Oncological Hadr…

cond-mat.mtrl-sci2016

Calcite single crystals as hosts for atomic-scale entrapment and slow release of drugs

Giulia Magnabosco, Matteo Di Giosia, Iryna Polishchuk +8

This study presents a complete structural and biological characterization of Doxorubicin CaCO3 single crystals as a pH responsive drug carrier. Using a biomimetic approach, it was…

physics.ins-det2016★ 35 cited

First Ex-Vivo Validation of a Radioguided Surgery Technique with beta- Radiation

E. Solfaroli Camillocci, M. Schiariti, V. Bocci +21

Purpose: A radio-guided surgery technique with beta- -emitting radio-tracers was suggested to overcome the effect of the large penetration of gamma radiation. The feasibility studi…

physics.med-ph2014★ 58 cited

Towards a Radio-guided Surgery with Decays: Uptake of a somatostatin analogue (DOTATOC) in Meningioma and High Grade Glioma

Francesco Collamati, Alessandra Pepe, Fabio Bellini +19

A novel radio guided surgery (RGS) technique for cerebral tumors using radiation is being developed. Checking the availability of a radio-tracer that can deliver a …

physics.med-ph2014★ 57 cited

A novel radioguided surgery technique exploiting decays

E. Solfaroli Camillocci, G. Baroni, F. Bellini +20

The background induced by the high penetration power of the gamma radiation is the main limiting factor of the current Radio-guided surgery (RGS). To partially mitigate it, a RGS w…

q-bio.TO2013★ 296 cited

A general framework for modeling tumor-immune system competition and immunotherapy: mathematical analysis and biomedical inferences

Alberto d'Onofrio

In this work we propose and investigate a family of models, which admits as particular cases some well known mathematical models of tumor-immune system interaction, with the additi…

q-bio.TO2013★ 70 cited

A non-linear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt

Alberto d'Onofrio, Ian P. M. Tomlinson

We present a development of a model of the relationship between cells in three compartments of the intestinal crypt: stem cells, semi-differentiated cells and fully differentiated…

q-bio.TO2013★ 38 cited

Fractal growth of tumors and other cellular populations: Linking the mechanistic to the phenomenological modeling and vice versa

Alberto d'Onofrio

In this paper we study and extend the mechanistic mean field theory of growth of cellular populations proposed by Mombach et al in (Mombach J. C. M. et al., Europhysics Letter, 59…

q-bio.PE2013★ 180 cited

Information-related changes in contact patterns may trigger oscillations in the endemic prevalence of infectious diseases

Alberto d'Onofrio, Piero Manfredi

It is well known that behavioral changes in contact patterns may significantly affect the spread of an epidemic outbreak. Here we focus on simple endemic models for recurrent epide…

q-bio.MN2012★ 11 cited

Cellular polarization: interaction between extrinsic bounded noises and wave-pinning mechanism

Sebastiano de Franciscis, Alberto d'Onofrio

Cued and un-cued cell polarization is a fundamental mechanism in cell biology. As an alternative to the classical Turing bifurcation, it has been proposed that the cell polarity mi…

cs.CE2012★ 6 cited

Effects of delayed immune-response in tumor immune-system interplay

Giulio Caravagna, Alex Graudenzi, Marco Antoniotti +2

Tumors constitute a wide family of diseases kinetically characterized by the co-presence of multiple spatio-temporal scales. So, tumor cells ecologically interplay with other kind…

q-bio.MN2012★ 56 cited

The interplay of intrinsic and extrinsic bounded noises in genetic networks

Giulio Caravagna, Giancarlo Mauri, Alberto d'Onofrio

After being considered as a nuisance to be filtered out, it became recently clear that biochemical noise plays a complex role, often fully functional, for a genetic network. The in…

cond-mat.stat-mech2012★ 17 cited

Spatio-temporal Bounded Noises, and transitions induced by them in solutions of real Ginzburg-Landau model

Sebastiano de Franciscis, Alberto d'Onofrio

In this work, we introduce two spatio-temporal colored bounded noises, based on the zero-dimensional Cai-Lin and Tsallis-Borland noises. We then study and characterize the dependen…

hep-ph2007★ 32 cited

Insensitivity of flavoured leptogenesis to low energy CP violation

Sacha Davidson, Julia Garayoa, Federica Palorini +1

If the baryon asymmetry of the Universe is produced by leptogenesis, CP violation is required in the lepton sector. In the seesaw extension of the Standard Model with three hierarc…