115 citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
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q-bio.BM2018★ 31 cited
Substrate inhibition imposes fitness penalty at high protein stability
Bharat V. Adkar, Sanchari Bhattacharyya, Amy I. Gilson +2
Proteins are only moderately stable. It has long been debated whether this narrow range of stabilities is solely a result of neutral drift towards lower stability or purifying sele…
q-bio.BM2012★ 115 cited
Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations
Shimon Bershtein, Wanmeng Mu, Eugene I. Shakhnovich
Mutations create the genetic diversity on which selective pressures can act, yet also create structural instability in proteins. How, then, is it possible for organisms to ameliora…