31 citations · 31 across the 2 of their papers we have counts for
2 papers
q-bio.BM2020
Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype
Sanchari Bhattacharyyaa, Shimon Bershtein, Bharat V. Adkara +2
The relationship between sequence variation and phenotype is poorly understood. Here we use metabolomic analysis to elucidate the molecular mechanism underlying the filamentous phe…
q-bio.BM2018★ 31 cited
Substrate inhibition imposes fitness penalty at high protein stability
Bharat V. Adkar, Sanchari Bhattacharyya, Amy I. Gilson +2
Proteins are only moderately stable. It has long been debated whether this narrow range of stabilities is solely a result of neutral drift towards lower stability or purifying sele…