57 citations · 145 across the 4 of their papers we have counts for
4 papers
Substrate inhibition imposes fitness penalty at high protein stability
Bharat V. Adkar, Sanchari Bhattacharyya, Amy I. Gilson +2
Proteins are only moderately stable. It has long been debated whether this narrow range of stabilities is solely a result of neutral drift towards lower stability or purifying sele…
Graph's Topology and Free Energy of a Spin Model on the Graph
Jeong-Mo Choi, Amy I. Gilson, Eugene I. Shakhnovich
In this work we show that there is a direct relationship between a graph's topology and the free energy of a spin system on the graph. We develop a method of separating topological…
Benchmarking inverse statistical approaches for protein structure and design with exactly solvable models
Hugo Jacquin, Amy Gilson, Eugene Shakhnovich +2
Inverse statistical approaches to determine protein structure and function from Multiple Sequence Alignments (MSA) are emerging as powerful tools in computational biology. However…
The role of evolutionary selection in the dynamics of protein structure evolution
Amy I. Gilson, Ahmee Marshall-Christensen, Jeong-Mo Choi +1
Emergence of new protein structures has proved difficult to trace in nature and engineer in the laboratory. However, one aspect of structure evolution has proved immensely helpful…