115 citations · 115 across the 2 of their papers we have counts for
2 papers
q-bio.BM2020
Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype
Sanchari Bhattacharyyaa, Shimon Bershtein, Bharat V. Adkara +2
The relationship between sequence variation and phenotype is poorly understood. Here we use metabolomic analysis to elucidate the molecular mechanism underlying the filamentous phe…
q-bio.BM2012★ 115 cited
Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations
Shimon Bershtein, Wanmeng Mu, Eugene I. Shakhnovich
Mutations create the genetic diversity on which selective pressures can act, yet also create structural instability in proteins. How, then, is it possible for organisms to ameliora…