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19942022
most citedLife is physics: evolution as a collective phenomenon far from equilibrium

293 citations

Showing q-bio.PEShow all

18 papers · 1 filter

q-bio.PE2020★ 107 cited

Time-dependent heterogeneity leads to transient suppression of the COVID-19 epidemic, not herd immunity

Alexei V. Tkachenko, Sergei Maslov, Ahmed Elbanna +3

Epidemics generally spread through a succession of waves that reflect factors on multiple timescales. On short timescales, super-spreading events lead to burstiness and overdispers…

q-bio.PE2020★ 30 cited

Modeling COVID-19 dynamics in Illinois under non-pharmaceutical interventions

George N. Wong, Zachary J. Weiner, Alexei V. Tkachenko +3

We present modeling of the COVID-19 epidemic in Illinois, USA, capturing the implementation of a Stay-at-Home order and scenarios for its eventual release. We use a non-Markovian a…

q-bio.PE2020★ 52 cited

Reaction-diffusion spatial modeling of COVID-19: Greece and Andalusia as case examples

P. G. Kevrekidis, J. Cuevas-Maraver, Y. Drossinos +2

We examine the spatial modeling of the outbreak of COVID-19 in two regions: the autonomous community of Andalusia in Spain and the mainland of Greece. We start with a 0D compartmen…

q-bio.PE2020★ 65 cited

Modeling microbial cross-feeding at intermediate scale portrays community dynamics and species coexistence

Chen Liao, Tong Wang, Sergei Maslov +1

Social interaction between microbes can be described at many levels of details, ranging from the biochemistry of cell-cell interactions to the ecological dynamics of populations. C…

q-bio.PE2019★ 63 cited

Evidence for a multi-level trophic organization of the human gut microbiome

Tong Wang, Akshit Goyal, Veronika Dubinkina +1

The human gut microbiome is a complex ecosystem, in which hundreds of microbial species and metabolites coexist, in part due to an extensive network of cross-feeding interactions.…

q-bio.PE2018

Alternative stable states in a model of microbial community limited by multiple essential nutrients

Veronika Dubinkina, Yulia Fridman, Parth Pandey +1

Microbial communities routinely have several alternative stable states observed for the same environmental parameters. Sudden and irreversible transitions between these states make…

q-bio.PE2017★ 103 cited

Multiple stable states in microbial communities explained by the stable marriage problem

Akshit Goyal, Veronika Dubinkina, Sergei Maslov

Experimental studies of microbial communities routinely reveal that they have multiple stable states. While each of these states is generally resilient, certain perturbations such…

q-bio.PE2017★ 87 cited

Diversity, stability, and reproducibility in stochastically assembled microbial ecosystems

Akshit Goyal, Sergei Maslov

Microbial ecosystems are remarkably diverse, stable, and often consist of a balanced mixture of core and peripheral species. Here we propose a conceptual model exhibiting all these…

q-bio.PE2017★ 29 cited

Onset of natural selection in auto-catalytic heteropolymers

Alexei V. Tkachenko, Sergei Maslov

Reduction of information entropy along with ever-increasing complexity are among the key signatures of living matter. Understanding the onset of such behavior in early prebiotic wo…

q-bio.PE2017★ 4 cited

Severe population collapses and species extinctions in multi-host epidemic dynamics

Sergei Maslov, Kim Sneppen

Most infectious diseases including more than half of known human pathogens are not restricted to just one host, yet much of the mathematical modeling of infections has been limited…

q-bio.PE2015★ 91 cited

A noise-induced mechanism for biological homochirality of early life self-replicators

Farshid Jafarpour, Tommaso Biancalani, Nigel Goldenfeld

The observed single-handedness of biological amino acids and sugars has long been attributed to autocatalysis. However, the stability of homochiral states in deterministic autocata…

q-bio.PE2015★ 10 cited

Diversity waves in collapse-driven population dynamics

Sergei Maslov, Kim Sneppen

Populations of species in ecosystems are often constrained by availability of resources within their environment. In effect this means that a growth of one population, needs to be…

q-bio.PE2014★ 22 cited

Path integral calculation for emergence of rapid evolution from demographic stochasticity

Hong-Yan Shih, Nigel Goldenfeld

Genetic variation in a population can sometimes arise so fast as to modify ecosystem dynamics. Such phenomena have been observed in natural predator-prey systems, and characterized…

q-bio.PE2010★ 16 cited

Statistical Mechanics of Horizontal Gene Transfer in Evolutionary Ecology

Nicholas Chia, Nigel Goldenfeld

The biological world, especially its majority microbial component, is strongly interacting and may be dominated by collective effects. In this review, we provide a brief introducti…

q-bio.PE2010★ 293 cited

Life is physics: evolution as a collective phenomenon far from equilibrium

Nigel Goldenfeld, Carl Woese

Evolution is the fundamental physical process that gives rise to biological phenomena. Yet it is widely treated as a subset of population genetics, and thus its scope is artificial…

q-bio.PE2010★ 14 cited

The dynamics of gene duplication and transposons in microbial genomes following a sudden environmental change

Nicholas Chia, Nigel Goldenfeld

A variety of genome transformations can occur as a microbial population adapts to a large environmental change. In particular, genomic surveys indicate that, following the transiti…

q-bio.PE2010★ 35 cited

Fixed points and limit cycles in the population dynamics of lysogenic viruses and their hosts

Zhenyu Wang, Nigel Goldenfeld

Starting with stochastic rate equations for the fundamental interactions between microbes and their viruses, we derive a mean field theory for the population dynamics of microbe-vi…

q-bio.PE2009★ 155 cited

Robust ecological pattern formation induced by demographic noise

Thomas Butler, Nigel Goldenfeld

We demonstrate that demographic noise can induce persistent spatial pattern formation and temporal oscillations in the Levin-Segel predator-prey model for plankton-herbivore popula…