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20122022
most citedFast Reconstruction of Compact Context-Specific Metabolic Network Models

289 citations

Showing q-bio.MNShow all

6 papers · 1 filter

q-bio.MN2016★ 21 cited

ReconMap: An interactive visualisation of human metabolism

Alberto Noronha, Anna Dröfn Danielsdóttir, Freyr Jóhannsson +8

A genome-scale reconstruction of human metabolism, Recon 2, is available but no interface exists to interactively visualise its content integrated with omics data and simulation re…

q-bio.MN2016★ 34 cited

Identification of conserved moieties in metabolic networks by graph theoretical analysis of atom transition networks

Hulda S. Haraldsdóttir, Ronan M. T. Fleming

Conserved moieties are groups of atoms that remain intact in all reactions of a metabolic network. Identification of conserved moieties gives insight into the structure and functio…

q-bio.MN2015

Conditions for duality between fluxes and concentrations in biochemical networks

Ronan M. T. Fleming, Nikos Vlassis, Ines Thiele +1

Mathematical and computational modelling of biochemical networks is often done in terms of either the concentrations of molecular species or the fluxes of biochemical reactions. Wh…

q-bio.MN2014★ 62 cited

Relative Stability of Network States in Boolean Network Models of Gene Regulation in Development

Joseph Xu Zhou, Areejit Samal, Aymeric Fouquier d'Hèrouël +2

Progress in cell type reprogramming has revived the interest in Waddington's concept of the epigenetic landscape. Recently researchers developed the quasi-potential theory to repre…

q-bio.MN2013★ 4 cited

Mesoscopic behavior from microscopic Markov dynamics and its application to calcium release channels

Nils Christian, Alexander Skupin, Silvia Morante +3

A major challenge in biology is to understand how molecular processes determine phenotypic features. We address this fundamental problem in a class of model systems by developing a…

q-bio.MN2013★ 289 cited

Fast Reconstruction of Compact Context-Specific Metabolic Network Models

Nikos Vlassis, Maria Pires Pacheco, Thomas Sauter

Systemic approaches to the study of a biological cell or tissue rely increasingly on the use of context-specific metabolic network models. The reconstruction of such a model from h…