39 citations · 55 across the 5 of their papers we have counts for
5 papers
Nonequilibrium calcium dynamics optimizes the energetic efficiency of mitochondrial metabolism
Valérie Voorsluijs, Francesco Avanzini, Gianmaria Falasco +2
Living organisms continuously harness energy to perform complex functions for their adaptation and survival while part of that energy is dissipated in the form of heat or chemical…
Buffering variability in cell regulation motifs close to criticality
Daniele Proverbio, Arthur N. Montanari, Alexander Skupin +1
Bistable biological regulatory systems need to cope with stochastic noise to fine-tune their function close to bifurcation points. Here, we study stability properties of this regim…
How to address cellular heterogeneity by distribution biology
Niko Komin, Alexander Skupin
Cellular heterogeneity is an immanent property of biological systems that covers very different aspects of life ranging from genetic diversity to cell-to-cell variability driven by…
Mesoscopic behavior from microscopic Markov dynamics and its application to calcium release channels
Nils Christian, Alexander Skupin, Silvia Morante +3
A major challenge in biology is to understand how molecular processes determine phenotypic features. We address this fundamental problem in a class of model systems by developing a…
Describing the complexity of systems: multi-variable "set complexity" and the information basis of systems biology
David J. Galas, Nikita A. Sakhanenko, Alexander Skupin +1
Context dependence is central to the description of complexity. Keying on the pairwise definition of "set complexity" we use an information theory approach to formulate general mea…