most citedAlternative Analysis Methods for Time to Event Endpoints under Non-proportional Hazards: A Comparative Analysis

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stat.AP2019★ 112 cited

Alternative Analysis Methods for Time to Event Endpoints under Non-proportional Hazards: A Comparative Analysis

Ray S. Lin, Ji Lin, Satrajit Roychoudhury +16

The log-rank test is most powerful under proportional hazards (PH). In practice, non-PH patterns are often observed in clinical trials, such as in immuno-oncology; therefore, alter…