most citedAlternative Analysis Methods for Time to Event Endpoints under Non-proportional Hazards: A Comparative Analysis

112 citations

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Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.

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2 papers

stat.ME2024

ZIKQ: An innovative centile chart method for utilizing natural history data in rare disease clinical development

Tianying Wang, Wenfei Zhang, Ying Wei

Utilizing natural history data as external control plays an important role in the clinical development of rare diseases, since placebo groups in double-blind randomization trials m…

stat.AP2019★ 112 cited

Alternative Analysis Methods for Time to Event Endpoints under Non-proportional Hazards: A Comparative Analysis

Ray S. Lin, Ji Lin, Satrajit Roychoudhury +16

The log-rank test is most powerful under proportional hazards (PH). In practice, non-PH patterns are often observed in clinical trials, such as in immuno-oncology; therefore, alter…