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9 papers · 1 filter
Depressed serum IgM levels in SLE are restricted to defined subgroups
Caroline Gronwall, Uta Hardt, Johanna T. Gustafsson +9
Natural IgM autoantibodies have been proposed to convey protection from autoimmune pathogenesis. Herein, we investigated the IgM responses in 396 systemic lupus erythematosus (SLE)…
Autoreactivity to malondialdehyde-modifications in rheumatoid arthritis is linked to disease activity and synovial pathogenesis
Caroline Gronwall, Khaled Amara, Uta Hardt +12
Oxidation-associated malondialdehyde (MDA) modification of proteins can generate immunogenic neo-epitopes that are recognized by autoantibodies. In health, IgM antibodies to MDA-ad…
Probabilistic Count Matrix Factorization for Single Cell Expression Data Analysis
Ghislain Durif, Laurent Modolo, Jeff E. Mold +2
The development of high throughput single-cell sequencing technologies now allows the investigation of the population level diversity of cellular transcriptomes. This diversity has…
Extended-Alphabet Finite-Context Models
João M. Carvalho, Susana Brás, Diogo Pratas +3
The Normalized Relative Compression (NRC) is a recent dissimilarity measure, related to the Kolmogorov Complexity. It has been successfully used in different applications, like DNA…
How to disentangle psychobiological stress reactivity and recovery: A comparison of model-based and non-compartmental analyses of cortisol concentrations
Robert Miller, Jan-Georg Wojtyniak, Lisa Weckesser +3
This article seeks to address the prevailing issue of how to measure specific process components of psychobiological stress responses. Particularly the change of cortisol secretion…
eSource for clinical trials: Implementation and evaluation of a standards-based approach in a real world trial
Jean-Francois Ethier, Vasa Curcin, Mark M. McGilchrist +9
Objective: The Learning Health System (LHS) requires integration of research into routine practice. eSource or embedding clinical trial functionalities into routine electronic heal…