output
20182025
most citedHomozygous GRN mutations: unexpected phenotypes and new insights into pathological and molecular mechanisms

97 citations

5 papers

physics.med-ph2025★ 2 cited

Millennium Pathways for Tractography: 40 grand challenges to shape the future of tractography

Maxime Descoteaux, Kurt G. Schilling, Dogu Baran Aydogan +44

In the spirit of the historic Millennium Prize Problems that heralded a new era for mathematics, the newly formed International Society for Tractography (IST) has launched the Mill…

math.OC2024★ 1 cited

Parameter estimation of hidden Markov models: comparison of EM and quasi-Newton methods with a new hybrid algorithm

Sidonie Foulon, Thérèse Truong, Anne-Louise Leutenegger +1

Hidden Markov Models (HMM) model a sequence of observations that are dependent on a hidden (or latent) state that follow a Markov chain. These models are widely used in diverse fie…

cs.LG2021★ 3 cited

Top-m identification for linear bandits

Clémence Réda, Emilie Kaufmann, Andrée Delahaye-Duriez

Motivated by an application to drug repurposing, we propose the first algorithms to tackle the identification of the m 1 arms with largest means in a linear bandit model, in…

q-bio.BM2020★ 97 cited

Homozygous GRN mutations: unexpected phenotypes and new insights into pathological and molecular mechanisms

Vincent Huin, Mathieu Barbier, Armand Bottani +18

Homozygous mutations in the progranulin gene (GRN) are associated with neuronal ceroid lipofuscinosis 11 (CLN11), a rare lysosomal-storage disorder characterized by cerebellar atax…

stat.AP2018★ 50 cited

Recent advances in methodology for clinical trials in small populations: the InSPiRe project

T. Friede, M. Posch, S. Zohar +19

Where there are a limited number of patients, such as in a rare disease, clinical trials in these small populations present several challenges, including statistical issues. This l…