output
20042026
most citedCell Detection with Star-convex Polygons

1.7k citations

Showing q-bio.TOShow all

8 papers · 1 filter

q-bio.TO2020

Letter to the Editor and Comments on: Intravital dynamic and correlative imaging reveals diffusion-dominated canalicular and flow-augmented ductular bile flux

Lutz Brusch, Yannis Kalaidzidis, Kirstin Meyer +2

Bile, the central metabolic product of the liver, is secreted by hepatocytes into bile canaliculi (BC), tubular subcellular structures of 0.5-2 m diameter which are formed by th…

q-bio.TO2019★ 20 cited

Resilience of three-dimensional sinusoidal networks in liver tissue

Jens Karschau, Andre Scholich, Jonathan Wise +4

Can three-dimensional, microvasculature networks still ensure blood supply if individual links fail? We address this question in the sinusoidal network, a plexus-like microvasculat…

q-bio.TO2019★ 12 cited

Quantification of Nematic Cell Polarity in Three-dimensional Tissues

André Scholich, Simon Syga, Hernán Morales-Navarrete +9

How epithelial cells coordinate their polarity to form functional tissues is an open question in cell biology. Here, we characterize a unique type of polarity found in liver tissue…

q-bio.TO2018★ 25 cited

Spontaneous symmetry breaking and pattern formation of organoids

Keisuke Ishihara, Elly M. Tanaka

Recent 3D organ reconstitution studies show that a group of stem cells can establish a body axis and acquire different fates in a spatially organized manner. How such symmetry brea…

q-bio.TO2016★ 97 cited

Triangles bridge the scales: Quantifying cellular contributions to tissue deformation

Matthias Merkel, Raphaël Etournay, Marko Popović +3

In this article, we propose a general framework to study the dynamics and topology of cellular networks that capture the geometry of cell packings in two-dimensional tissues. Such…

q-bio.TO2015★ 12 cited

A Method for Modeling Growth of Organs and Transplants Based on the General Growth Law: Application to the Liver in Dogs and Humans

Yuri K. Shestopaloff, Ivo F. Sbalzarini

Understanding biological phenomena requires a systemic approach that incorporates different mechanisms acting on different spatial and temporal scales, since in organisms the worki…

q-bio.TO2014★ 85 cited

Scaling and regeneration of self-organized patterns

Steffen Werner, Tom Stückemann, Manuel Beirán Amigo +3

Biological patterns generated during development and regeneration often scale with organism size. Some organisms, e.g., flatworms, can regenerate a rescaled body plan from tissue f…

q-bio.TO2010★ 178 cited

Intercellular Coupling Regulates the Period of the Segmentation Clock

Leah Herrgen, Saul Ares, Luis G. Morelli +3

Coupled biological oscillators can tick with the same period. How this collective period is established is a key question in understanding biological clocks. We explore this questi…