90 citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- Université de RennesFR16 papers
- InsermFR5 papers
- École des Hautes Études en Santé PubliqueFR4 papers
- Heka : Méthodes basées sur les données et modèles en santé pour l'acquisition de connaissancesFR3 papers
- Infection, Anti-microbiens, Modélisation, EvolutionFR3 papers
- Institut de recherche mathématique de RennesFR3 papers
- Sorbonne Paris CitéFR3 papers
- Sorbonne UniversitéFR3 papers
- UCLouvainBE3 papers
- Université Paris CitéFR3 papers
- Université Rennes 1FR3 papers
- Assistance Publique – Hôpitaux de ParisFR2 papers
19 papers
In silico clinical trials in drug development: a systematic review
Bohua Chen, Lucia Chantal Schneider, Christian Röver +15
In the context of clinical research, computational models have received increasing attention over the past decades. In this systematic review, we aimed to provide an overview of th…
Straightforward Phase I Dose-Finding Design for Healthy Volunteers Accounting for Surrogate Activity Biomarkers
Sandrine Boulet, Emmanuelle Comets, Antoine Guillon +5
Conventionally, a first-in-human phase I trial in healthy volunteers aims to confirm the safety of a drug in humans. In such situations, volunteers should not suffer from any safet…
Test of the formal basis of Arrhenius law with heat capacities
Denis Michel
The exponential factor of Arrhenius satisfactorily quantifies the energetic restriction of chemical reactions but is still awaiting a rigorous basis. Assuming that the Arrhenius eq…
Bayesian Framework for Multi-Source Data Integration -- Application to Human Extrapolation From Preclinical Studies
Sandrine Boulet, Moreno Ursino, Robin Michelet +4
In preclinical investigations, e.g. in in vitro, in vivo and in silico studies, the pharmacokinetic, pharmacodynamic and toxicological characteristics of a drug are evaluated befor…
State-of-the-Art Methods for Exposure-Health Studies: results from the Exposome Data Challenge Event
Léa Maitre, Jean-Baptiste Guimbaud, Charline Warembourg +7
The exposome recognizes that individuals are exposed simultaneously to a multitude of different environmental factors and takes a holistic approach to the discovery of etiological…
Galilean and relativistic Doppler/aberration effects deduced from spherical and ellipsoidal wavefronts respectively
Denis Michel
The diagram showing off-center nested spheres which is traditionally used to illustrate the Doppler effect, is misleading and its trigonometric analysis leads to errors concerning…
Reflection on modern methods: a note on variance estimation when using inverse probability weighting to handle attrition in cohort studies
Marie-Astrid Metten, Nathalie Costet, J. -F. Viel +1
The inverse probability weighting (IPW) method is used to handle attrition in association analyses derived from cohort studies. It consists in weighting the respondents at a given…
The basal level of gene expression associated with chromatin loosening shapes Waddington landscapes and controls cell differentiation
Gilles Flouriot, Charly Jehanno, Yann Le Page +3
The baseline level of transcription, which is variable and difficult to quantify, seriously complicates the normalization of comparative transcriptomic data, but its biological imp…
Reductionist approach to chemical rate constants using conditional energy probabilities
Denis Michel
Different rate theories yielded similar forms of rates constants consistent with the phenomenological Arrhenius law, although they were derived from various branches of physics inc…
Polylogarithmic equilibrium treatment of molecular aggregation and critical concentrations
Denis Michel, Philippe Ruelle
A full equilibrium treatment of molecular aggregation is presented for prototypes of 1D and 3D aggregates, with and without nucleation. By skipping complex kinetic parameters like…
Modeling generic aspects of ideal fibril formation
Denis Michel
Many different proteins self-aggregate into insoluble fibrils growing apically by reversible addition of elementary building blocks. But beyond this common principle, the modalitie…
Drawing a Waddington landscape to capture dynamic epigenetics
Floriane Nicol-Benoit, Pascale le Goff, Denis Michel
Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores…
Conformational selection or induced fit? New insights from old principles
Denis Michel
A long standing debate in biochemistry is to determine whether the conformational changes observed during biomolecular interactions proceed through conformational selection (of pre…
The accuracy of biochemical interactions is ensured by endothermic stepwise kinetics
Denis Michel, Benjamin Boutin, Philippe Ruelle
The discerning behavior of living systems relies on accurate interactions selected from the lot of molecular collisions occurring in the cell. To ensure the reliability of interact…
A role for ATP-dependent chromatin remodeling in the hierarchical cooperativity between noninteracting transcription factors
Denis Michel
Chromatin remodeling machineries are abundant and diverse in eukaryotic cells. They have been involved in a variety of situations such as histone exchange and DNA repair, but their…
New treatments of density fluctuations and recurrence times for re-estimating Zermelo's paradox
Denis Michel
What is the probability that all the gas in a box accumulates in the same half of this box? Though amusing, this question underlies the fundamental problem of density fluctuations…
Kinetic approaches to lactose operon induction and bimodality
Denis Michel
The quasi-equilibrium approximation is acceptable when molecular interactions are fast enough compared to circuit dynamics, but is no longer allowed when cellular activities are go…
Seven competing ways to recover the Michaelis-Menten equation reveal the alternative approaches to steady state modeling
Denis Michel, Philippe Ruelle
The Michaelis-Menten enzymatic reaction is sufficient to perceive many subtleties of network modeling, including the concentration and time scales separations, the formal equivalen…
Simply conceiving the Arrhenius law and absolute kinetic constants using the geometric distribution
Denis Michel
Although first-order rate constants are basic ingredients of physical chemistry, biochemistry and systems modeling, their innermost nature is derived from complex physical chemistr…