90 citations
- Université de RennesFR11 papers
- InsermFR4 papers
- École des Hautes Études en Santé PubliqueFR3 papers
- Heka : Méthodes basées sur les données et modèles en santé pour l'acquisition de connaissancesFR3 papers
- Infection, Anti-microbiens, Modélisation, EvolutionFR3 papers
- Sorbonne Paris CitéFR3 papers
- Sorbonne UniversitéFR3 papers
- Université Paris CitéFR3 papers
- Assistance Publique – Hôpitaux de ParisFR2 papers
- Centre de Recherche des CordeliersFR2 papers
- Freie Universität BerlinDE2 papers
- Institut de recherche mathématique de RennesFR2 papers
15 papers
In silico clinical trials in drug development: a systematic review
Bohua Chen, Lucia Chantal Schneider, Christian Röver +15
In the context of clinical research, computational models have received increasing attention over the past decades. In this systematic review, we aimed to provide an overview of th…
Straightforward Phase I Dose-Finding Design for Healthy Volunteers Accounting for Surrogate Activity Biomarkers
Sandrine Boulet, Emmanuelle Comets, Antoine Guillon +5
Conventionally, a first-in-human phase I trial in healthy volunteers aims to confirm the safety of a drug in humans. In such situations, volunteers should not suffer from any safet…
Test of the formal basis of Arrhenius law with heat capacities
Denis Michel
The exponential factor of Arrhenius satisfactorily quantifies the energetic restriction of chemical reactions but is still awaiting a rigorous basis. Assuming that the Arrhenius eq…
Bayesian Framework for Multi-Source Data Integration -- Application to Human Extrapolation From Preclinical Studies
Sandrine Boulet, Moreno Ursino, Robin Michelet +4
In preclinical investigations, e.g. in in vitro, in vivo and in silico studies, the pharmacokinetic, pharmacodynamic and toxicological characteristics of a drug are evaluated befor…
State-of-the-Art Methods for Exposure-Health Studies: results from the Exposome Data Challenge Event
Léa Maitre, Jean-Baptiste Guimbaud, Charline Warembourg +7
The exposome recognizes that individuals are exposed simultaneously to a multitude of different environmental factors and takes a holistic approach to the discovery of etiological…
Galilean and relativistic Doppler/aberration effects deduced from spherical and ellipsoidal wavefronts respectively
Denis Michel
The diagram showing off-center nested spheres which is traditionally used to illustrate the Doppler effect, is misleading and its trigonometric analysis leads to errors concerning…