157 citations
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- Institut de Recherche en Santé, Environnement et TravailFR3 papers
- Université de RennesFR3 papers
- Centre de Recherche des CordeliersFR2 papers
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- Heka : Méthodes basées sur les données et modèles en santé pour l'acquisition de connaissancesFR2 papers
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14 papers
Sinkhorn Hamiltonian Monte Carlo for Entropic Optimal Transport Generalized Bayes
Guilhem Nespoulous, Fr{é}d{é}ric Bertrand, Myriam Maumy +1
Bayesian posterior sampling is a ubiquitous paradigm for problems where a point estimate of parameters is not sufficient, such as risk analysis and uncertainty quantification. Howe…
Straightforward Phase I Dose-Finding Design for Healthy Volunteers Accounting for Surrogate Activity Biomarkers
Sandrine Boulet, Emmanuelle Comets, Antoine Guillon +5
Conventionally, a first-in-human phase I trial in healthy volunteers aims to confirm the safety of a drug in humans. In such situations, volunteers should not suffer from any safet…
Bayesian Framework for Multi-Source Data Integration -- Application to Human Extrapolation From Preclinical Studies
Sandrine Boulet, Moreno Ursino, Robin Michelet +4
In preclinical investigations, e.g. in in vitro, in vivo and in silico studies, the pharmacokinetic, pharmacodynamic and toxicological characteristics of a drug are evaluated befor…
State-of-the-Art Methods for Exposure-Health Studies: results from the Exposome Data Challenge Event
Léa Maitre, Jean-Baptiste Guimbaud, Charline Warembourg +7
The exposome recognizes that individuals are exposed simultaneously to a multitude of different environmental factors and takes a holistic approach to the discovery of etiological…
On detecting weak changes in the mean of CHARN models
Joseph Ngatchou-Wandji, Marwa Ltaifa
We study a likelihood ratio test for detecting multiple {\it weak} changes in the mean of a class of CHARN models. The locally asymptotically normal (LAN) structure of the family o…
The basal level of gene expression associated with chromatin loosening shapes Waddington landscapes and controls cell differentiation
Gilles Flouriot, Charly Jehanno, Yann Le Page +3
The baseline level of transcription, which is variable and difficult to quantify, seriously complicates the normalization of comparative transcriptomic data, but its biological imp…