3 papers
stat.ME2020
Bayesian model for early dose-finding in phase I trials with multiple treatment courses
Moreno Ursino, Lucie Biard, Sylvie Chevret
Dose-finding clinical trials in oncology aim to determine the maximum tolerated dose (MTD) of a new drug, generally defined by the proportion of patients with short-term dose-limit…
q-bio.QM2019
Random-effects meta-analysis of phase I dose-finding studies using stochastic process priors
Moreno Ursino, Christian Röver, Sarah Zohar +1
Phase I dose-finding studies aim at identifying the maximal tolerated dose (MTD). It is not uncommon that several dose-finding studies are conducted, although often with some varia…
stat.AP2018
Recent advances in methodology for clinical trials in small populations: the InSPiRe project
T. Friede, M. Posch, S. Zohar +19
Where there are a limited number of patients, such as in a rare disease, clinical trials in these small populations present several challenges, including statistical issues. This l…