50 citations · 78 across the 13 of their papers we have counts for
3 papers · 1 filter
PK/PD-integrated Bayesian platform design for phase II dose regimen optimization
Axel Vuorinen, Antoine Guillon, Emmanuelle Comets +2
Early-phase dose-finding methods increasingly assess toxicity and efficacy jointly, but comparisons based only on administered dose may inadequately characterize regimens differing…
Conditional bootstrap for non-linear mixed effects models
Sofia Kaisaridi, Moreno Ursino, Emmanuelle Comets
Background and Objective: Uncertainty in non-linear mixed effect models is often assessed using the Fisher information matrix to derive the standard errors of estimation. The boots…
Latent Neural-ODE for Model-Informed Precision Dosing: Overcoming Structural Assumptions in Pharmacokinetics
Benjamin Maurel, Agathe Guilloux, Sarah Zohar +2
Accurate estimation of tacrolimus exposure, quantified by the area under the concentration-time curve (AUC), is essential for precision dosing after renal transplantation. Current…