225 citations
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7 papers · 1 filter
Environment heterogeneity creates fast amplifiers of natural selection in graph-structured populations
Cecilia Fruet, Arthur Alexandre, Alia Abbara +2
Complex spatial structure, with partially isolated subpopulations, and environment heterogeneity, such as gradients in nutrients, oxygen, and drugs, both shape the evolution of nat…
Spatial structure facilitates evolutionary rescue by drug resistance
Cecilia Fruet, Ella Linxia Müller, Claude Loverdo +1
Bacterial populations often have complex spatial structures, which can impact their evolution. Here, we study how spatial structure affects the evolution of antibiotic resistance i…
Bridging Wright-Fisher and Moran models
Arthur Alexandre, Alia Abbara, Cecilia Fruet +2
The Wright-Fisher model and the Moran model are both widely used in population genetics. They describe the time evolution of the frequency of an allele in a well-mixed population w…
Toward a universal model for spatially structured populations
Loïc Marrec, Irene Lamberti, Anne-Florence Bitbol
A key question in evolution is how likely a mutant is to take over. This depends on natural selection and on stochastic fluctuations. Population spatial structure can impact mutant…
Adapt or perish: Evolutionary rescue in a gradually deteriorating environment
Loïc Marrec, Anne-Florence Bitbol
We investigate the evolutionary rescue of a microbial population in a gradually deteriorating environment, through a combination of analytical calculations and stochastic simulatio…
Resist or perish: fate of a microbial population subjected to a periodic presence of antimicrobial
Loïc Marrec, Anne-Florence Bitbol
The evolution of antimicrobial resistance can be strongly affected by variations of antimicrobial concentration. Here, we study the impact of periodic alternations of absence and p…