5 papers
Adapt or perish: Evolutionary rescue in a gradually deteriorating environment
Loïc Marrec, Anne-Florence Bitbol
We investigate the evolutionary rescue of a microbial population in a gradually deteriorating environment, through a combination of analytical calculations and stochastic simulatio…
Resist or perish: fate of a microbial population subjected to a periodic presence of antimicrobial
Loïc Marrec, Anne-Florence Bitbol
The evolution of antimicrobial resistance can be strongly affected by variations of antimicrobial concentration. Here, we study the impact of periodic alternations of absence and p…
Symmetry in cancer networks identified: Proposal for multi-cancer biomarkers
Pramod Shinde, Loic Marrec, Aparna Rai +5
One of the most challenging problems in biomedicine and genomics is the identification of disease biomarkers. In this study, proteomics data from seven major cancers were used to c…
Antibody-mediated cross-linking of gut bacteria hinders the spread of antibiotic resistance
Florence Bansept, Loïc Marrec, Anne-Florence Bitbol +1
The body is home to a diverse microbiota, mainly in the gut. Resistant bacteria are selected for by antibiotic treatments, and once resistance becomes widespread in a population of…
Quantifying the impact of a periodic presence of antimicrobial on resistance evolution in a homogeneous microbial population of fixed size
Loïc Marrec, Anne-Florence Bitbol
The evolution of antimicrobial resistance generally occurs in an environment where antimicrobial concentration is variable, which has dramatic consequences on the microorganisms' f…