510 citations
- University of EdinburghGB26 papers
- Edinburgh GenomicsGB3 papers
- UK Astronomy Technology CentreGB3 papers
- University of BergenNO3 papers
- Biomathematics and Statistics ScotlandGB2 papers
- Curtin UniversityAU2 papers
- Heriot-Watt UniversityGB2 papers
- International Centre for Radio Astronomy ResearchAU2 papers
- Karolinska InstitutetSE2 papers
- McGill UniversityCA2 papers
- The Queen's Medical Research InstituteGB2 papers
- University of California, DavisUS2 papers
6 papers · 1 filter
Efficient and accurate causal inference with hidden confounders from genome-transcriptome variation data
Lingfei Wang, Tom Michoel
Mapping gene expression as a quantitative trait using whole genome-sequencing and transcriptome analysis allows to discover the functional consequences of genetic variation. We dev…
Functional transcription factor target discovery via compendia of binding and expression profiles
Christopher J. Banks, Anagha Joshi, Tom Michoel
Genome-wide experiments to map the DNA-binding locations of transcription-associated factors (TFs) have shown that the number of genes bound by a TF far exceeds the number of possi…
Integrative multi-omics module network inference with Lemon-Tree
Eric Bonnet, Laurence Calzone, Tom Michoel
Module network inference is an established statistical method to reconstruct co-expression modules and their upstream regulatory programs from integrated multi-omics datasets measu…
Multi-species network inference improves gene regulatory network reconstruction for early embryonic development in Drosophila
Anagha Joshi, Yvonne Beck, Tom Michoel
Gene regulatory network inference uses genome-wide transcriptome measurements in response to genetic, environmental or dynamic perturbations to predict causal regulatory influences…
kruX: Matrix-based non-parametric eQTL discovery
Jianlong Qi, Hassan Foroughi Asl, Johan Bjorkegren +1
The Kruskal-Wallis test is a popular non-parametric statistical test for identifying expression quantitative trait loci (eQTLs) from genome-wide data due to its robustness against…
Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation
A. R. R. Forrest, M. Kanamori-Katayama, Y. Tomaru +12
Acute myeloid leukemia (AML) involves a block in terminal differentiation of the myeloid lineage and uncontrolled proliferation of a progenitor state. Using phorbol myristate aceta…