1.1k citations
6 papers
Controlling false discoveries in Bayesian gene networks with lasso regression p-values
Lingfei Wang, Tom Michoel
Bayesian networks can represent directed gene regulations and therefore are favored over co-expression networks. However, hardly any Bayesian network study concerns the false disco…
Evaluation of tools for differential gene expression analysis by RNA-seq on a 48 biological replicate experiment
Nicholas J. Schurch, Pieta Schofield, Marek Gierliński +9
An RNA-seq experiment with 48 biological replicates in each of 2 conditions was performed to determine the number of biological replicates () required, and to identify the mos…
Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment
Marek Gierliński, Christian Cole, Pietà Schofield +9
High-throughput RNA sequencing (RNA-seq) is now the standard method to determine differential gene expression. Identifying differentially expressed genes crucially depends on estim…
A scalable method for molecular network reconstruction identifies properties of targets and mutations in acute myeloid leukemia
Edison Ong, Anthony Szedlak, Yunyi Kang +9
A key aim of systems biology is the reconstruction of molecular networks, however we do not yet have networks that integrate information from all datasets available for a particula…
Multi-species network inference improves gene regulatory network reconstruction for early embryonic development in Drosophila
Anagha Joshi, Yvonne Beck, Tom Michoel
Gene regulatory network inference uses genome-wide transcriptome measurements in response to genetic, environmental or dynamic perturbations to predict causal regulatory influences…
The complex hybrid origins of the root knot nematodes revealed through comparative genomics
David H Lunt, Sujai Kumar, Georgios Koutsovoulos +1
Meloidogyne root knot nematodes (RKN) can infect most of the world's agricultural crop species and are among the most important of all plant pathogens. As yet however we have littl…