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6 papers · 1 filter
Latent variable model selection for Gaussian conditional random fields
Benjamin Frot, Luke Jostins, Gil McVean
We consider the problem of learning a conditional Gaussian graphical model in the presence of latent variables. Building on recent advances in this field, we suggest a method that…
Identifying lineage effects when controlling for population structure improves power in bacterial association studies
Sarah G Earle, Chieh-Hsi Wu, Jane Charlesworth +16
Bacteria pose unique challenges for genome-wide association studies (GWAS) because of strong structuring into distinct strains and substantial linkage disequilibrium across the gen…
Predictable patterns of CTL escape and reversion across host populations and viral subtypes in HIV-1 evolution
Duncan S. Palmer, Emily Adland, John A. Frater +7
The twin processes of viral evolutionary escape and reversion in response to host immune pressure, in particular the cytotoxic T-lymphocyte (CTL) response, shape Human Immunodefici…
The Hamming Ball Sampler
Michalis K. Titsias, Christopher Yau
We introduce the Hamming Ball Sampler, a novel Markov Chain Monte Carlo algorithm, for efficient inference in statistical models involving high-dimensional discrete state spaces. T…
Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections
Bethany L. Dearlove, Alison J. Cody, Ben Pascoe +3
Campylobacter jejuni and Campylobacter coli are the biggest causes of bacterial gastroenteritis in the developed world, with human infections typically arising from zoonotic transm…
CoMaLit-IV. Evolution and self-similarity of scaling relations with the galaxy cluster mass
Mauro Sereno, Stefano Ettori
The scaling of observable properties of galaxy clusters with mass evolves with time. Assessing the role of the evolution is crucial to study the formation and evolution of massive…