4 papers
Supervised variable selection in randomised controlled trials prior to exploration of treatment effect heterogeneity: an example from severe malaria
Chieh-Hsi Wu, Chris C. Holmes
Exploration of treatment effect heterogeneity (TEH) is an increasingly important aspect of modern statistical analysis for stratified medicine in randomised controlled trials (RCTs…
SCOTTI: Efficient Reconstruction of Transmission within Outbreaks with the Structured Coalescent
Nicola De Maio, Chieh-Hsi Wu, Daniel J Wilson
Exploiting pathogen genomes to reconstruct transmission represents a powerful tool in the fight against infectious disease. However, their interpretation rests on a number of simpl…
Identifying lineage effects when controlling for population structure improves power in bacterial association studies
Sarah G Earle, Chieh-Hsi Wu, Jane Charlesworth +16
Bacteria pose unique challenges for genome-wide association studies (GWAS) because of strong structuring into distinct strains and substantial linkage disequilibrium across the gen…
New Routes to Phylogeography
Nicola De Maio, Chieh-Hsi Wu, Kathleen M O'Reilly +1
Phylogeographic methods aim to infer migration trends and the history of sampled lineages from genetic data. Applications of phylogeography are broad, and in the context of pathoge…