21 citations · 31 across the 6 of their papers we have counts for
6 papers
Latent variable model selection for Gaussian conditional random fields
Benjamin Frot, Luke Jostins, Gil McVean
We consider the problem of learning a conditional Gaussian graphical model in the presence of latent variables. Building on recent advances in this field, we suggest a method that…
Identifying lineage effects when controlling for population structure improves power in bacterial association studies
Sarah G Earle, Chieh-Hsi Wu, Jane Charlesworth +16
Bacteria pose unique challenges for genome-wide association studies (GWAS) because of strong structuring into distinct strains and substantial linkage disequilibrium across the gen…
Predictable patterns of CTL escape and reversion across host populations and viral subtypes in HIV-1 evolution
Duncan S. Palmer, Emily Adland, John A. Frater +7
The twin processes of viral evolutionary escape and reversion in response to host immune pressure, in particular the cytotoxic T-lymphocyte (CTL) response, shape Human Immunodefici…
Identifying recombination hotspots using population genetic data
Adam Auton, Simon Myers, Gil McVean
Motivation: Recombination rates vary considerably at the fine scale within mammalian genomes, with the majority of recombination occurring within hotspots of ~2 kb in width. We pre…
Demography and the age of rare variants
Iain Mathieson, Gil McVean
Large whole-genome sequencing projects have provided access to much of the rare variation in human populations, which is highly informative about population structure and recent de…
Integrating genealogical and dynamical modelling to infer escape and reversion rates in HIV epitopes
Duncan Palmer, John Frater, Rodney Philips +2
The rates of escape and reversion in response to selection pressure arising from the host immune system, notably the cytotoxic T-lymphocyte (CTL) response, are key factors determin…