206 citations · 636 across the 20 of their papers we have counts for
20 papers
Functional analysis of a gene locus in response to non-canonical combinations of transcription factors
Netta Haroush, Michal Levo, Eric Wieschaus +1
Transcription factor combinations determine gene locus activity and thereby cell identity. However, the precise link between concentrations of such activating transcription factors…
Gene activity fully predicts transcriptional bursting dynamics
Po-Ta Chen, Michal Levo, Benjamin Zoller +1
Transcription commonly occurs in bursts, with alternating productive (ON) and quiescent (OFF) periods, governing mRNA production rates. Yet, how transcription is regulated through…
Precise and scalable self-organization in mammalian pseudo-embryos
Melody Merle, Leah Friedman, Corinne Chureau +2
Gene expression is inherently noisy, posing a challenge to understanding how precise and reproducible patterns of gene expression emerge in mammals. We investigate this phenomenon…
Deriving a genetic regulatory network from an optimization principle
Thomas R Sokolowski, Thomas Gregor, William Bialek +1
Many biological systems approach physical limits to their performance, motivating the idea that their behavior and underlying mechanisms could be determined by such optimality. Nev…
Eukaryotic gene regulation at equilibrium, or non?
Benjamin Zoller, Thomas Gregor, Gašper Tkačik
Models of transcriptional regulation that assume equilibrium binding of transcription factors have been very successful at predicting gene expression from sequence in bacteria. How…
Transcription-dependent spatial organization of a gene locus
Lev Barinov, Sergey Ryabichko, William Bialek +1
There is growing appreciation that gene function is connected to the dynamic structure of the chromosome. Here we explore the interplay between three-dimensional structure and tran…