206 citations · 636 across the 20 of their papers we have counts for
4 papers · 1 filter
Functional analysis of a gene locus in response to non-canonical combinations of transcription factors
Netta Haroush, Michal Levo, Eric Wieschaus +1
Transcription factor combinations determine gene locus activity and thereby cell identity. However, the precise link between concentrations of such activating transcription factors…
Gene activity fully predicts transcriptional bursting dynamics
Po-Ta Chen, Michal Levo, Benjamin Zoller +1
Transcription commonly occurs in bursts, with alternating productive (ON) and quiescent (OFF) periods, governing mRNA production rates. Yet, how transcription is regulated through…
Precise and scalable self-organization in mammalian pseudo-embryos
Melody Merle, Leah Friedman, Corinne Chureau +2
Gene expression is inherently noisy, posing a challenge to understanding how precise and reproducible patterns of gene expression emerge in mammals. We investigate this phenomenon…
Deriving a genetic regulatory network from an optimization principle
Thomas R Sokolowski, Thomas Gregor, William Bialek +1
Many biological systems approach physical limits to their performance, motivating the idea that their behavior and underlying mechanisms could be determined by such optimality. Nev…