61 citations · 183 across the 31 of their papers we have counts for
11 papers · 1 filter
Multiscale hemodynamics model for the pulmonary arteries, arterioles, capillaries, venules and veins
Michelle A Bartolo, Mansoor A Haider, Nicholas A Hill +1
This study presents the first mathematical model of pulsatile hemodynamics that encompasses the complete pulmonary circulation, explicitly linking the large arteries, arterioles, c…
Computational framework for the generation of one-dimensional vascular models accounting for uncertainty in networks extracted from medical images
Michelle A Bartolo, Alyssa M Taylor-LaPole, Darsh Gandhi +9
Patient-specific computational modeling is a popular, non-invasive method to answer medical questions. Medical images are used to extract geometric domains necessary to create thes…
Characterization of differences in immune responses during bolus and continuous infusion endotoxin challenges using mathematical modeling
Kristen A. Windoloski, Susanne Janum, Ronan M. G. Berg +1
Endotoxin administration is commonly used to study the inflammatory response, and though traditionally given as a bolus injection, it can be administered as a continuous infusion o…
A unified model for the human response to lipopolysaccharide-induced inflammation
Kristen A. Windoloski, Elisabeth O. Bansgaard, Atanaska Dobreva +2
This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharid…
Application and reduction of a nonlinear hyperelastic wall model capturing ex vivo relationships between fluid pressure, area and wall thickness in normal and hypertensive murine left pulmonary arteries
Mansoor A. Haider, Katherine J. Pearce, Naomi C. Chesler +2
Pulmonary hypertension is a cardiovascular disorder manifested by elevated arterial blood pressure together with vessel wall stiffening and thickening due to alterations in collage…
Postural Orthostatic Tachycardia Syndrome explained using abaroreflex response model
Justen Geddes, Johnny T Ottesen, Jesper Mehlsen +1
Recent studies have shown that Postural Orthostatic Tachycardia Syndrome (POTS) patients have abnormal low frequency Hz blood pressure and heart rate dynamics. These…
Numerical predictions of shear stress and cyclic stretch in the healthy pulmonary vasculature
Michelle A. Bartolo, M. Umar Qureshi, Mitchel J. Colebank +2
Isolated post-capillary pulmonary hypertension (Ipc-PH) occurs due to left heart failure, which contributes to 1 out of every 9 deaths in the United States. In some patients, throu…
A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension
Mitchel J. Colebank, M. Umar Qureshi, Sudarshan Rajagopal +2
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by recurrent or unresolved pulmonary thromboemboli, leading to perfusion defects and increased arterial wave reflect…
A physiological model of the inflammatory-thermal-pain-cardiovascular interactions during a pathogen challenge
Atanaska Dobreva, Renee Brady, Kamila Larripa +3
Uncontrolled, excessive production of pro-inflammatory mediators from immune cells and traumatized tissues can cause systemic inflammatory issues like sepsis, one of the ten leadin…
Deep phenotyping of cardiac function in heart transplant patients using cardiovascular systems models
Amanda L. Colunga, Karam G. Kim, N. Payton Woodall +4
Heart transplant patients are followed with periodic right heart catheterizations (RHCs) to identify post-transplant complications and guide treatment. Post-transplant positive out…
Mathematical model of the interaction between baroreflex and cerebral autoregulation
Adam Mahdi, Mette S. Olufsen, Stephen J. Payne
Baroreflex (BR) and cerebral autoregulation (CA) are two important mechanisms regulating blood pressure and flow. However, the functional relationship between BR and CA in humans i…