61 citations · 183 across the 31 of their papers we have counts for
31 papers
Multiscale hemodynamics model for the pulmonary arteries, arterioles, capillaries, venules and veins
Michelle A Bartolo, Mansoor A Haider, Nicholas A Hill +1
This study presents the first mathematical model of pulsatile hemodynamics that encompasses the complete pulmonary circulation, explicitly linking the large arteries, arterioles, c…
A One Dimensional (1D) Computational Fluid Dynamics Study of Fontan-Associated Liver Disease (FALD)
Yaqi Li, Justin D. Weigand, Charles Puelz +2
Fontan-Associated Liver Disease (FALD) is a disorder arising from hemodynamic changes and venous congestion in the liver. This disease is prominent in patients with hypoplastic lef…
Parameter selection and optimization of a computational network model of blood flow in single-ventricle patients
Alyssa M. Taylor-LaPole, L. Mihaela Paun, Dan Lior +3
Hypoplastic left heart syndrome (HLHS) is a congenital heart disease responsible for 23% of infant cardiac deaths each year. HLHS patients are born with an underdeveloped left hear…
Computational framework for the generation of one-dimensional vascular models accounting for uncertainty in networks extracted from medical images
Michelle A Bartolo, Alyssa M Taylor-LaPole, Darsh Gandhi +9
Patient-specific computational modeling is a popular, non-invasive method to answer medical questions. Medical images are used to extract geometric domains necessary to create thes…
Characterization of differences in immune responses during bolus and continuous infusion endotoxin challenges using mathematical modeling
Kristen A. Windoloski, Susanne Janum, Ronan M. G. Berg +1
Endotoxin administration is commonly used to study the inflammatory response, and though traditionally given as a bolus injection, it can be administered as a continuous infusion o…
A Topological Data Analysis Study on Murine Pulmonary Arterial Trees with Pulmonary Hypertension
Megan Chambers, Natalie Johnston, Ian Livengood +3
Pulmonary hypertension (PH), defined by a mean pulmonary arterial blood pressure above 20 mmHg, is a cardiovascular disease impacting the pulmonary vasculature. PH is accompanied b…
A unified model for the human response to lipopolysaccharide-induced inflammation
Kristen A. Windoloski, Elisabeth O. Bansgaard, Atanaska Dobreva +2
This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharid…
Post-processing of coronary and myocardial spatial data
Jay Aodh Mackenzie, Megan Jeanne Miller, Nicholas Hill +1
Numerical simulations of real-world phenomena require a computational scheme and a computational domain. In the context of haemodynamics, the computational domain is the blood vess…
A computational study of aortic reconstruction in single ventricle patients
Alyssa M. Taylor-LaPole, Mitchel J. Colebank, Justin D. Weigand +2
Patients with hypoplastic left heart syndrome (HLHS) are born with an underdeveloped left heart. They typically receive a sequence of surgeries that result in a single ventricle ph…
Application and reduction of a nonlinear hyperelastic wall model capturing ex vivo relationships between fluid pressure, area and wall thickness in normal and hypertensive murine left pulmonary arteries
Mansoor A. Haider, Katherine J. Pearce, Naomi C. Chesler +2
Pulmonary hypertension is a cardiovascular disorder manifested by elevated arterial blood pressure together with vessel wall stiffening and thickening due to alterations in collage…
Postural Orthostatic Tachycardia Syndrome explained using abaroreflex response model
Justen Geddes, Johnny T Ottesen, Jesper Mehlsen +1
Recent studies have shown that Postural Orthostatic Tachycardia Syndrome (POTS) patients have abnormal low frequency Hz blood pressure and heart rate dynamics. These…
Numerical predictions of shear stress and cyclic stretch in the healthy pulmonary vasculature
Michelle A. Bartolo, M. Umar Qureshi, Mitchel J. Colebank +2
Isolated post-capillary pulmonary hypertension (Ipc-PH) occurs due to left heart failure, which contributes to 1 out of every 9 deaths in the United States. In some patients, throu…
Synthesizing Skeletal Motion and Physiological Signals as a Function of a Virtual Human's Actions and Emotions
Bonny Banerjee, Masoumeh Heidari Kapourchali, Murchana Baruah +3
Round-the-clock monitoring of human behavior and emotions is required in many healthcare applications which is very expensive but can be automated using machine learning (ML) and s…
A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension
Mitchel J. Colebank, M. Umar Qureshi, Sudarshan Rajagopal +2
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by recurrent or unresolved pulmonary thromboemboli, leading to perfusion defects and increased arterial wave reflect…
Parameter inference in a computational model of hemodynamics in pulmonary hypertension
Amanda L. Colunga, Mitchel J. Colebank, REU Program +1
Pulmonary hypertension (PH), defined by a mean pulmonary arterial pressure (mPAP) 20 mmHg, is characterized by increased pulmonary vascular resistance and decreased pulmonary a…
Global sensitivity analysis informed model reduction and selection applied to a Valsalva maneuver model
E. Benjamin Randall, Nicholas Z. Randolph, Alen Alexanderian +1
In this study, we develop a methodology for model reduction and selection informed by global sensitivity analysis (GSA) methods. We apply these techniques to a control model that t…
Structural and hemodynamic properties in murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension
Megan J. Chambers, Mitchel J. Colebank, M Umar Qureshi +2
Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and h…
Characterization of blood pressure and heart rate oscillations of POTS patients via uniform phase empirical mode decomposition
Justen Geddes, Jesper Mehlsen, Mette S. Olufsen
Objective: Postural Orthostatic Tachycardia Syndrome (POTS) is associated with the onset of tachycardia upon postural change. The current diagnosis involves the measurement of hear…
A physiological model of the inflammatory-thermal-pain-cardiovascular interactions during a pathogen challenge
Atanaska Dobreva, Renee Brady, Kamila Larripa +3
Uncontrolled, excessive production of pro-inflammatory mediators from immune cells and traumatized tissues can cause systemic inflammatory issues like sepsis, one of the ten leadin…
Persistent instability in a nonhomogeneous delay differential equation system of the Valsalva maneuver
E. Benjamin Randall, Nicholas Z. Randolph, Mette S. Olufsen
Delay differential equations (DDEs) are widely used in mathematical modeling to describe physical and biological systems. Delays can impact model dynamics, resulting in oscillatory…
Influence of image segmentation on one-dimensional fluid dynamics predictions in the mouse pulmonary arteries
Mitchel J. Colebank, L. Mihaela Paun, M. Umar Qureshi +4
Computational fluid dynamics (CFD) models are emerging as tools for assisting in diagnostic assessment of cardiovascular disease. Recent advances in image segmentation has made sub…
Deep phenotyping of cardiac function in heart transplant patients using cardiovascular systems models
Amanda L. Colunga, Karam G. Kim, N. Payton Woodall +4
Heart transplant patients are followed with periodic right heart catheterizations (RHCs) to identify post-transplant complications and guide treatment. Post-transplant positive out…
Sensitivity analysis and uncertainty quantification of 1D models of the pulmonary circulation
Mitchel J. Colebank, M. Umar Qureshi, Mette S. Olufsen
This study combines a one-dimensional (1D) model with micro-CT imaging and hemodynamic data to quantify uncertainty of flow and pressure predictions in the pulmonary arteries in a…
MCMC methods for inference in a mathematical model of pulmonary circulation
L. Mihaela Paun, M. Umar Qureshi, Mitchel Colebank +4
This study performs parameter inference in a partial differential equations system of pulmonary circulation. We use a fluid dynamics network model that takes selected parameter val…