61 citations · 183 across the 31 of their papers we have counts for
11 papers · 1 filter
Parameter selection and optimization of a computational network model of blood flow in single-ventricle patients
Alyssa M. Taylor-LaPole, L. Mihaela Paun, Dan Lior +3
Hypoplastic left heart syndrome (HLHS) is a congenital heart disease responsible for 23% of infant cardiac deaths each year. HLHS patients are born with an underdeveloped left hear…
A Topological Data Analysis Study on Murine Pulmonary Arterial Trees with Pulmonary Hypertension
Megan Chambers, Natalie Johnston, Ian Livengood +3
Pulmonary hypertension (PH), defined by a mean pulmonary arterial blood pressure above 20 mmHg, is a cardiovascular disease impacting the pulmonary vasculature. PH is accompanied b…
Parameter inference in a computational model of hemodynamics in pulmonary hypertension
Amanda L. Colunga, Mitchel J. Colebank, REU Program +1
Pulmonary hypertension (PH), defined by a mean pulmonary arterial pressure (mPAP) 20 mmHg, is characterized by increased pulmonary vascular resistance and decreased pulmonary a…
Global sensitivity analysis informed model reduction and selection applied to a Valsalva maneuver model
E. Benjamin Randall, Nicholas Z. Randolph, Alen Alexanderian +1
In this study, we develop a methodology for model reduction and selection informed by global sensitivity analysis (GSA) methods. We apply these techniques to a control model that t…
Structural and hemodynamic properties in murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension
Megan J. Chambers, Mitchel J. Colebank, M Umar Qureshi +2
Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and h…
Characterization of blood pressure and heart rate oscillations of POTS patients via uniform phase empirical mode decomposition
Justen Geddes, Jesper Mehlsen, Mette S. Olufsen
Objective: Postural Orthostatic Tachycardia Syndrome (POTS) is associated with the onset of tachycardia upon postural change. The current diagnosis involves the measurement of hear…
Influence of image segmentation on one-dimensional fluid dynamics predictions in the mouse pulmonary arteries
Mitchel J. Colebank, L. Mihaela Paun, M. Umar Qureshi +4
Computational fluid dynamics (CFD) models are emerging as tools for assisting in diagnostic assessment of cardiovascular disease. Recent advances in image segmentation has made sub…
Practical Identifiability and Uncertainty Quantification of a Pulsatile Cardiovascular Model
Andrew D. Marquis, Andrea Arnold, Caron Dean +2
Mathematical models are essential tools to study how the cardiovascular system maintains homeostasis. The utility of such models is limited by the accuracy of their predictions, wh…
Increased blood pressure variability upon standing up improves reproducibility of cerebral autoregulation indices
Adam Mahdi, Dragana Nikolic, Anthony A. Birch +4
Dynamic cerebral autoregulation, that is the transient response of cerebral blood flow to changes in arterial blood pressure, is currently assessed using a variety of different tim…
Classification of syncope through data analytics
Joseph Hart, Jesper Mehlsen, Christian H. Olsen +2
Objective: Syncope is a sudden loss of consciousness with loss of postural tone and spontaneous recovery; it is a common condition, albeit one that is challenging to accurately dia…
Personalized Mathematical Model Predicting Endotoxin-Induced Inflammatory Responses in Young Men
Renee Brady, Dennis O. Frank-Ito, Hien T. Tran +6
The initial reaction of the body to pathogenic microbial infection or severe tissue trauma is an acute inflammatory response. The magnitude of such a response is of critical import…