171 citations · 630 across the 10 of their papers we have counts for
10 papers
Heterologous autoimmunity and prokaryotic immune defense
Hanrong Chen, Andreas Mayer, Vijay Balasubramanian
Some prokaryotes possess CRISPR-Cas systems that provide adaptive immunity to viruses guided by DNA segments called spacers acquired from invading phage. However, the patchy incide…
Tregs self-organize into a "computing ecosystem" and implement a sophisticated optimization algorithm for mediating immune response
Robert Marsland, Owen Howell, Andreas Mayer +1
Regulatory T cells (Tregs) play a crucial role in mediating immune response. Yet an algorithmic understanding of the role of Tregs in adaptive immunity remains lacking. Here, we pr…
Early life imprints the hierarchy of T cell clone sizes
Mario U. Gaimann, Maximilian Nguyen, Jonathan Desponds +1
The adaptive immune system responds to pathogens by selecting clones of cells with specific receptors. While clonal selection in response to particular antigens has been studied in…
Receptor crosstalk improves concentration sensing of multiple ligands
Martin Carballo-Pacheco, Jonathan Desponds, Tatyana Gavrilchenko +5
Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface…
Regulation of T cell expansion by antigen presentation dynamics
Andreas Mayer, Yaojun Zhang, Alan S. Perelson +1
An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells. This proli…
How a well-adapting immune system remembers
Andreas Mayer, Vijay Balasubramanian, Aleksandra M. Walczak +1
An adaptive agent predicting the future state of an environment must weigh trust in new observations against prior experiences. In this light, we propose a view of the adaptive imm…