171 citations · 630 across the 10 of their papers we have counts for
9 papers · 1 filter
Heterologous autoimmunity and prokaryotic immune defense
Hanrong Chen, Andreas Mayer, Vijay Balasubramanian
Some prokaryotes possess CRISPR-Cas systems that provide adaptive immunity to viruses guided by DNA segments called spacers acquired from invading phage. However, the patchy incide…
Tregs self-organize into a "computing ecosystem" and implement a sophisticated optimization algorithm for mediating immune response
Robert Marsland, Owen Howell, Andreas Mayer +1
Regulatory T cells (Tregs) play a crucial role in mediating immune response. Yet an algorithmic understanding of the role of Tregs in adaptive immunity remains lacking. Here, we pr…
Early life imprints the hierarchy of T cell clone sizes
Mario U. Gaimann, Maximilian Nguyen, Jonathan Desponds +1
The adaptive immune system responds to pathogens by selecting clones of cells with specific receptors. While clonal selection in response to particular antigens has been studied in…
Regulation of T cell expansion by antigen presentation dynamics
Andreas Mayer, Yaojun Zhang, Alan S. Perelson +1
An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells. This proli…
How a well-adapting immune system remembers
Andreas Mayer, Vijay Balasubramanian, Aleksandra M. Walczak +1
An adaptive agent predicting the future state of an environment must weigh trust in new observations against prior experiences. In this light, we propose a view of the adaptive imm…
Transitions in optimal adaptive strategies for populations in fluctuating environments
Andreas Mayer, Thierry Mora, Olivier Rivoire +1
Biological populations are subject to fluctuating environmental conditions. Different adaptive strategies can allow them to cope with these fluctuations: specialization to one part…
Population dynamics of immune repertoires
Jonathan Desponds, Andreas Mayer, Thierry Mora +1
The evolution of the adaptive immune system is characterized by changes in the relative abundances of the B- and T-cell clones that make up its repertoires. To fully capture this e…
Diversity of immune strategies explained by adaptation to pathogen statistics
Andreas Mayer, Thierry Mora, Olivier Rivoire +1
Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ in how protection is a…
How a well-adapted immune system is organized
Andreas Mayer, Vijay Balasubramanian, Thierry Mora +1
The repertoire of lymphocyte receptors in the adaptive immune system protects organisms from diverse pathogens. A well-adapted repertoire should be tuned to the pathogenic environm…