491 citations · 3.8k across the 67 of their papers we have counts for
7 papers · 1 filter
Fundamental Limits on Sensing Chemical Concentrations with Linear Biochemical Networks
Christopher C. Govern, Pieter Rein ten Wolde
Living cells often need to extract information from biochemical signals that are noisy. We study how accurately cells can measure chemical concentrations with signaling networks th…
The macroscopic effects of microscopic heterogeneity
Andrew Mugler, Pieter Rein ten Wolde
Over the past decade, advances in super-resolution microscopy and particle-based modeling have driven an intense interest in investigating spatial heterogeneity at the level of sin…
Mutual Repression enhances the Steepness and Precision of Gene Expression Boundaries
Thomas R. Sokolowski, Thorsten Erdmann, Pieter Rein ten Wolde
Embryonic development is driven by spatial patterns of gene expression that determine the fate of each cell in the embryo. While gene expression is often highly erratic, embryonic…
Signalling noise enhances chemotactic drift of E. coli
Marlo Flores, Thomas S. Shimuzu, Pieter Rein ten Wolde +1
Noise in transduction of chemotactic stimuli to the flagellar motor of E. coli will affect the random run-and-tumble motion of the cell and the ability to perform chemotaxis. Here…
Reliability of frequency- and amplitude-decoding in gene regulation
Filipe Tostevin, Wiet de Ronde, Pieter Rein ten Wolde
In biochemical signaling, information is often encoded in oscillatory signals. However, the advantages of such a coding strategy over an amplitude encoding scheme of constant signa…
Rare switching events in non-stationary systems
Nils B. Becker, Pieter Rein ten Wolde
Physical systems with many degrees of freedom can often be understood in terms of transitions between a small number of metastable states. For time-homogeneous systems with short-t…
Non-Stationary Forward Flux Sampling
Nils B. Becker, Rosalind J. Allen, Pieter Rein ten Wolde
We present a new method, Non-Stationary Forward Flux Sampling, that allows efficient simulation of rare events in both stationary and non-stationary stochastic systems. The method…