491 citations · 3.8k across the 67 of their papers we have counts for
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q-bio.MN2004
Chemical models of genetic toggle switches
Patrick B. Warren, Pieter Rein ten Wolde
We study by mean-field analysis and stochastic simulations chemical models for genetic toggle switches formed from pairs of genes that mutually repress each other. In order to dete…
q-bio.MN2004★ 491 cited
Sampling rare switching events in biochemical networks
Rosalind J. Allen, Patrick B. Warren, Pieter Rein ten Wolde
Bistable biochemical switches are ubiquitous in gene regulatory networks and signal transduction pathways. Their switching dynamics, however, are difficult to study directly in exp…