172 citations · 423 across the 10 of their papers we have counts for
10 papers
A matter of time: Using dynamics and theory to uncover mechanisms of transcriptional bursting
Nicholas C. Lammers, Yang Joon Kim, Jiaxi Zhao +1
Eukaryotic transcription generally occurs in bursts of activity lasting minutes to hours; however, state-of-the-art measurements have revealed that many of the molecular processes…
Figure 1 Theory Meets Figure 2 Experiments in the Study of Gene Expression
Rob Phillips, Nathan M. Belliveau, Griffin Chure +3
It is tempting to believe that we now own the genome. The ability to read and re-write it at will has ushered in a stunning period in the history of science. Nonetheless, there is…
DNA sequence-dependent mechanics and protein-assisted bending in repressor-mediated loop formation
James Q. Boedicker, Hernan G. Garcia, Stephanie Johnson +1
As the chief informational molecule of life, DNA is subject to extensive physical manipulations. The energy required to deform double-helical DNA depends on sequence, and this mech…
Effect of promoter architecture on the cell-to-cell variability in gene expression
Alvaro Sanchez, Hernan Garcia, Daniel Jones +2
According to recent experimental evidence, the architecture of a promoter, defined as the number, strength and regulatory role of the operators that control the promoter, plays a m…
Concentration and Length Dependence of DNA Looping in Transcriptional Regulation
Lin Han, Hernan G. Garcia, Seth Blumberg +4
In many cases, transcriptional regulation involves the binding of transcription factors at sites on the DNA that are not immediately adjacent to the promoter of interest. This acti…
First-principles calculation of DNA looping in tethered particle experiments
Kevin B. Towles, John F. Beausang, Hernan G. Garcia +2
We calculate the probability of DNA loop formation mediated by regulatory proteins such as Lac repressor (LacI), using a mathematical model of DNA elasticity. Our model is adapted…