4 papers
Informational blueprints reveal condition-dependent gene regulatory architectures
Doruk Efe Gökmen, Rosalind Wenshan Pan, Tom Röschinger +4
While coding regions in the genome have a direct interpretation in terms of protein products, significant fractions are non-coding and yet control essential biological functions. U…
Biological Processes as Exploratory Dynamics
Jane Kondev, Marc Kirschner, Hernan G. Garcia +2
Many biological processes can be thought of as the result of an underlying dynamics in which the system repeatedly undergoes distinct and abortive trajectories with the dynamical p…
The Dynamics of Inducible Genetic Circuits
Zitao Yang, Rebecca J. Rousseau, Sara D. Mahdavi +2
Genes are connected in complex networks of interactions where often the product of one gene is a transcription factor that alters the expression of another. Many of these networks…
Deciphering regulatory architectures from synthetic single-cell expression patterns
Rosalind Wenshan Pan, Tom Roeschinger, Kian Faizi +2
For the vast majority of genes in sequenced genomes, there is limited understanding of how they are regulated. Without such knowledge, it is not possible to perform a quantitative…