71 citations · 405 across the 25 of their papers we have counts for
25 papers
Modelling realistic 3D deformations of simple epithelia in dynamic homeostasis
Domenic P. J. Germano, Stuart T. Johnston, Edmund J. Crampin +1
The maintenance of tissue and organ structures during dynamic homeostasis is often not well understood. In order for a system to be stable, cell renewal, cell migration and cell de…
Multiscale modelling of desquamation in the interfollicular epidermis
Claire Miller, Edmund Crampin, James Osborne
Maintenance of epidermal thickness is critical to the barrier function of the skin. Decreased tissue thickness, specifically in the stratum corneum (the outermost layer of the tiss…
Predicting population extinction in lattice-based birth-death-movement models
Stuart T. Johnston, Matthew J. Simpson, Edmund J. Crampin
The question of whether a population will persist or go extinct is of key interest throughout ecology and biology. Various mathematical techniques allow us to generate knowledge re…
Computer-aided modelling of complex physical systems with BondGraphTools
Peter Cudmore, Peter J. Gawthrop, Michael Pan +1
BondGraphTools is a Python library for scripted modelling of complex multi-physics systems. In contrast to existing modelling solutions, BondGraphTools is based upon the well estab…
Physically-Plausible Modelling of Biomolecular Systems: A Simplified, Energy-Based Model of the Mitochondrial Electron Transport Chain
Peter J. Gawthrop, Peter Cudmore, Edmund J. Crampin
Systems biology and whole-cell modelling are demanding increasingly comprehensive mathematical models of cellular biochemistry. These models require the development of simplified m…
Ca2+ release via IP3 receptors shapes the cytosolic Ca2+ transient for hypertrophic signalling in ventricular cardiomyocytes
Hilary Hunt, Agne Tilunaite, Greg Bass +4
Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signalling in ventricular cardiomyocytes. L-type Ca2+ channels trigger release of Ca2+ f…