239 citations · 412 across the 24 of their papers we have counts for
4 papers · 1 filter
Transcriptional bursting in gene expression: analytical results for general stochastic models
Niraj Kumar, Abhyudai Singh, Rahul V. Kulkarni
Gene expression in individual cells is highly variable and sporadic, often resulting in the synthesis of mRNAs and proteins in bursts. Bursting in gene expression is known to impac…
Moment Closure Approximations in a Genetic Negative Feedback Circuit
Mohammad Soltani, Cesar Vargas, Niraj Kumar +2
Auto-regulation, a process wherein a protein negatively regulates its own production, is a common motif in gene expression networks. Negative feedback in gene expression plays a cr…
Optimal first-passage time in gene regulatory networks
Khem Raj Ghusinga, Abhyudai Singh
The inherent probabilistic nature of the biochemical reactions, and low copy number of species can lead to stochasticity in gene expression across identical cells. As a result, aft…
Nonspecific transcription factor binding reduces variability in transcription factor and target protein expression
Mohammad Soltani, Pavol Bokes, Zachary Fox +1
Transcription factors (TFs) interact with a multitude of binding sites on DNA and partner proteins inside cells. We investigate how nonspecific binding/unbinding to such decoy bind…