205 citations · 221 across the 16 of their papers we have counts for
5 papers · 1 filter
Theoretical and computational tools to model multistable gene regulatory networks
Federico Bocci, Dongya Jia, Qing Nie +2
The last decade has witnessed a surge of theoretical and computational models to describe the dynamics of complex gene regulatory networks, and how these interactions can give rise…
Understanding the principles of pattern formation driven by Notch signaling by integrating experiments and theoretical models
Federico Bocci, Jose Nelson Onuchic, Mohit Kumar Jolly
Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the em…
Mathematical Modeling of Plasticity and Heterogeneity in EMT
Shubham Tripathi, Jianhua Xing, Herbert Levine +1
Epithelial-Mesenchymal Transition (EMT), and the corresponding reverse process, Mesenchymal-Epithelial Transition (MET), are dynamic and reversible cellular programs orchestrated b…
Deciphering the dynamics of Epithelial-Mesenchymal Transition and Cancer Stem Cells in tumor progression
Federico Bocci, Herbert Levine, José Nelson Onuchic +1
Purpose of review: The epithelial-Mesenchymal Transition (EMT) and the generation of Cancer Stem Cells (CSC) are two fundamental aspects contributing to tumor growth, acquisition o…
Analysis of hierarchical organization in gene expression networks reveals underlying principles of collective tumor cell dissemination and metastatic aggressiveness of inflammatory breast cancer
Shubham Tripathi, Mohit Kumar Jolly, Wendy A. Woodward +2
Clusters of circulating tumor cells (CTCs), although rare, may account for more than 95% of metastases. Inflammatory breast cancer (IBC) is a highly aggressive subtype that chiefly…