49 citations · 69 across the 12 of their papers we have counts for
16 papers
A universal multi-turnpike principle for optimal allocation of translational resources
Ram Massas, Thomas Kriecherbauer, Lars Grüne +2
mRNA translation in the cell requires efficient allocation of shared and limited resources including free ribosomes, tRNA molecules, and initiation factors across multiple transcri…
Variability in mRNA Translation: A Random Matrix Theory Approach
Michael Margaliot, Wasim Huleihel, Tamir Tuller
The rate of mRNA translation depends on the initiation, elongation, and termination rates of ribosomes along the mRNA. These rates depend on many "local" factors like the abundance…
Networks of ribosome flow models for modeling and analyzing intracellular traffic
Itzik Nanikashvili, Yoram Zarai, Alexander Ovseevich +2
The ribosome flow model with input and output (RFMIO) is a deterministic dynamical system that has been used to study the flow of ribosomes during mRNA translation. The RFMIO and i…
Ribosome Flow Model with Extended Objects
Yoram Zarai, Michael Margaliot, Tamir Tuller
We study a deterministic mechanistic model for the flow of ribosomes along the mRNA molecule, called the ribosome flow model with extended objects (RFMEO). This model encapsulates…
A Deterministic Mathematical Model for Bidirectional Excluded Flow with Langmuir Kinetics
Yoram Zarai, Michael Margaliot, Tamir Tuller
In many important cellular processes, including mRNA translation, gene transcription, phosphotransfer, and intracellular transport, biological "particles" move along some kind of "…
On the Ribosomal Density that Maximizes Protein Translation Rate
Yoram Zarai, Michael Margaliot, Tamir Tuller
During mRNA translation, several ribosomes attach to the same mRNA molecule simultaneously translating it into a protein. This pipelining increases the protein production rate. A n…