221 citations · 932 across the 42 of their papers we have counts for
5 papers · 1 filter
An introduction to reconstructing ancestral genomes
Lior Pachter
Recent advances in high-throughput genomics technologies have resulted in the sequencing of large numbers of (near) complete genomes. These genome sequences are being mined for imp…
Towards the Human Genotope
Peter Huggins, Lior Pachter, Bernd Sturmfels
The human genotope is the convex hull of all allele frequency vectors that can be obtained from the genotypes present in the human population. In this paper we take a few initial s…
Geometry of rank tests
Jason Morton, Lior Pachter, Anne Shiu +2
We study partitions of the symmetric group which have desirable geometric properties. The statistical tests defined by such partitions involve counting all permutations in the equi…
Epistasis and Shapes of Fitness Landscapes
Niko Beerenwinkel, Lior Pachter, Bernd Sturmfels
The relationship between the shape of a fitness landscape and the underlying gene interactions, or epistasis, has been extensively studied in the two-locus case. Gene interactions…
Why neighbor-joining works
Radu Mihaescu, Dan Levy, Lior Pachter
We show that the neighbor-joining algorithm is a robust quartet method for constructing trees from distances. This leads to a new performance guarantee that contains Atteson's opti…