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Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination
Yuval Elhanati, Zachary Sethna, Curtis G. Callan +2
Despite the extreme diversity of T cell repertoires, many identical T-cell receptor (TCR) sequences are found in a large number of individual mice and humans. These widely-shared s…
Mouse T cell repertoires as statistical ensembles: overall characterization and age dependence
Zachary Sethna, Yuval Elhanati, Crissy S. Dudgeon +4
The ability of the adaptive immune system to respond to arbitrary pathogens stems from the broad diversity of immune cell surface receptors (TCRs). This diversity originates in a s…
Maximum entropy models for antibody diversity
Thierry Mora, Aleksandra Walczak, William Bialek +1
Recognition of pathogens relies on families of proteins showing great diversity. Here we construct maximum entropy models of the sequence repertoire, building on recent experiments…