2 papers
q-bio.BM2024
Data-driven Discovery of Biophysical T Cell Receptor Co-specificity Rules
Andrew G. T. Pyo, Yuta Nagano, Martina Milighetti +5
The biophysical interactions between the T cell receptor (TCR) and its ligands determine the specificity of the cellular immune response. However, the immense diversity of receptor…
q-bio.GN2018
OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs
Zachary Sethna, Yuval Elhanati, Curtis G. Callan +2
Motivation: High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination of T- and…