261 citations · 262 across the 3 of their papers we have counts for
3 papers
Data-driven Discovery of Biophysical T Cell Receptor Co-specificity Rules
Andrew G. T. Pyo, Yuta Nagano, Martina Milighetti +5
The biophysical interactions between the T cell receptor (TCR) and its ligands determine the specificity of the cellular immune response. However, the immense diversity of receptor…
Maximum entropy models for patterns of gene expression
Camilla Sarra, Leopoldo Sarra, Luca Di Carlo +4
New experimental methods make it possible to measure the expression levels of many genes, simultaneously, in snapshots from thousands or even millions of individual cells. Current…
OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs
Zachary Sethna, Yuval Elhanati, Curtis G. Callan +2
Motivation: High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination of T- and…