1.1k citations · 6.9k across the 33 of their papers we have counts for
33 papers
Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination
Yuval Elhanati, Zachary Sethna, Curtis G. Callan +2
Despite the extreme diversity of T cell repertoires, many identical T-cell receptor (TCR) sequences are found in a large number of individual mice and humans. These widely-shared s…
Mouse T cell repertoires as statistical ensembles: overall characterization and age dependence
Zachary Sethna, Yuval Elhanati, Crissy S. Dudgeon +4
The ability of the adaptive immune system to respond to arbitrary pathogens stems from the broad diversity of immune cell surface receptors (TCRs). This diversity originates in a s…
Inferring processes underlying B-cell repertoire diversity
Yuval Elhanati, Zachary Sethna, Quentin Marcou +3
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-…
Quantifying selection in immune receptor repertoires
Yuval Elhanati, Anand Murugan, Curtis G. Callan +2
The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity result…
Statistical inference of the generation probability of T-cell receptors from sequence repertoires
Anand Murugan, Thierry Mora, Aleksandra M. Walczak +1
Stochastic rearrangement of germline DNA by VDJ recombination is at the origin of immune system diversity. This process is implemented via a series of stochastic molecular events i…
Maximum entropy models for antibody diversity
Thierry Mora, Aleksandra Walczak, William Bialek +1
Recognition of pathogens relies on families of proteins showing great diversity. Here we construct maximum entropy models of the sequence repertoire, building on recent experiments…