2.2k citations · 3.1k across the 14 of their papers we have counts for
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Diversity in immunogenomics: the value and the challenge
Kerui Peng, Yana Safonova, Mikhail Shugay +32
With the advent of high-throughput sequencing technologies, the fields of immunogenomics and adaptive immune receptor repertoire research are facing both opportunities and challeng…
Addressing Ancestry Disparities in Genomic Medicine: A Geographic-aware Algorithm
Daniel Mas Montserrat, Arvind Kumar, Carlos Bustamante +1
With declining sequencing costs a promising and affordable tool is emerging in cancer diagnostics: genomics. By using association studies, genomic variants that predispose patients…
LAI-Net: Local-Ancestry Inference with Neural Networks
Daniel Mas Montserrat, Carlos Bustamante, Alexander Ioannidis
Local-ancestry inference (LAI), also referred to as ancestry deconvolution, provides high-resolution ancestry estimation along the human genome. In both research and industry, LAI…
Class-Conditional VAE-GAN for Local-Ancestry Simulation
Daniel Mas Montserrat, Carlos Bustamante, Alexander Ioannidis
Local ancestry inference (LAI) allows identification of the ancestry of all chromosomal segments in admixed individuals, and it is a critical step in the analysis of human genomes…
Genome Sequencing Highlights Genes Under Selection and the Dynamic Early History of Dogs
Adam H. Freedman, Rena M. Schweizer, Ilan Gronau +27
To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we analyzed novel high-quality genome sequences of three gray wolves, one…
Improved haplotyping of rare variants using next-generation sequence data
Fouad Zakharia, Carlos Bustamante
Accurate identification of haplotypes in sequenced human genomes can provide invaluable information about population demography and fine-scale correlations along the genome, thus e…