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Reconstructing continuous distributions of 3D protein structure from cryo-EM images
Ellen D. Zhong, Tristan Bepler, Joseph H. Davis +1
Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structure of proteins and other macromolecular complexes at near-atomic resolution. In single particl…
Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs
Tristan Bepler, Andrew Morin, Julia Brasch +3
Cryo-electron microscopy (cryoEM) is an increasingly popular method for protein structure determination. However, identifying a sufficient number of particles for analysis (often >…
Enabling Privacy-Preserving GWAS in Heterogeneous Human Populations
Sean Simmons, Cenk Sahinalp, Bonnie Berger
The projected increase of genotyping in the clinic and the rise of large genomic databases has led to the possibility of using patient medical data to perform genomewide associatio…
Low-density locality-sensitive hashing boosts metagenomic binning
Yunan Luo, Jianyang Zeng, Bonnie Berger +1
Metagenomic binning is an essential task in analyzing metagenomic sequence datasets. To analyze structure or function of microbial communities from environmental samples, metagenom…