326 citations · 563 across the 5 of their papers we have counts for
5 papers
Protein and DNA sequence determinants of thermophilic adaptation
Konstantin B. Zeldovich, Igor N. Berezovsky, Eugene I. Shakhnovich
Prokaryotes living at extreme environmental temperatures exhibit pronounced signatures in the amino acid composition of their proteins and nucleotide compositions of their genomes…
Positive and negative design in stability and thermal adaptation of natural proteins
Igor N. Berezovsky, Konstantin B. Zeldovich, Eugene I. Shakhnovich
The aim of this work is to elucidate how physical principles of protein design are reflected in natural sequences that evolved in response to the thermal conditions of the environm…
Physical origins of protein superfamilies
Konstantin B. Zeldovich, Igor N. Berezovsky, Eugene I. Sha
In this work, we discovered a fundamental connection between selection for protein stability and emergence of preferred structures of proteins. Using standard exact 3-dimensional l…
Entropic stabilization of proteins and its proteomic consequences
Igor N. Berezovsky, William W. Chen, Paul J. Choi +1
We report here a new entropic mechanism of protein thermostability due to residual dynamics of rotamer isomerization in native state. All-atom simulations show that Lysines have mu…
Of sequence and structure: Strategies of protein thermostability in evolutionary perspective
Igor N. Berezovsky, Eugene I. Shakhnovich
In this work we employ various methods of analysis (unfolding simulations and comparative analysis of structures and sequences of proteomes of thermophilic organisms) to show that…