62 citations · 197 across the 13 of their papers we have counts for
14 papers
Universal principles of cell population growth follow from local contact inhibition
Gregory J. Kimmel, Sadegh Marzban, Mehdi Damaghi +4
Cancer cell populations often exhibit remarkably similar growth laws despite their heterogeneity. Explanations of universal cell population growth remain partly unresolved to this…
Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments
Aleksandra Ardaševa, Robert A. Gatenby, Alexander R. A. Anderson +3
Living species, ranging from bacteria to animals, exist in environmental conditions that exhibit spatial and temporal heterogeneity which requires them to adapt. Risk-spreading thr…
The impact of cellular characteristics on the evolution of shape homeostasis
Philip Gerlee, David Basanta, Alexander R. A. Anderson
The importance of individual cells in a developing multicellular organism is well known but precisely how the individual cellular characteristics of those cells collectively drive…
Bridging scales in cancer progression: Mapping genotype to phenotype using neural networks
Philip Gerlee, Eunjung Kim, Alexander R. A. Anderson
In this review we summarize our recent efforts in trying to understand the role of heterogeneity in cancer progression by using neural networks to characterise different aspects of…
The evolution of carrying capacity in constrained and expanding tumour cell populations
Philip Gerlee, Alexander R. A. Anderson
Cancer cells are known to modify their micro-environment such that it can sustain a larger population, or, in ecological terms, they construct a niche which increases the carrying…
Mathematical modeling of the metastatic process
Jacob G. Scott, Philip Gerlee, David Basanta +3
Mathematical modeling in cancer has been growing in popularity and impact since its inception in 1932. The first theoretical mathematical modeling in cancer research was focused on…