62 citations · 197 across the 13 of their papers we have counts for
6 papers · 1 filter
Mathematical modeling of the metastatic process
Jacob G. Scott, Philip Gerlee, David Basanta +3
Mathematical modeling in cancer has been growing in popularity and impact since its inception in 1932. The first theoretical mathematical modeling in cancer research was focused on…
Exploiting ecological principles to better understand cancer progression and treatment
David Basanta, Alexander R. A. Anderson
A small but growing number of people are finding interesting parallels between ecosystems as studied by ecologists (think of a Savanna or the Amazon rain forest or a Coral reef) an…
Evolution of intratumoral phenotypic heterogeneity: the role of trait inheritance
Jill Gallaher, Alexander R. A. Anderson
A tumor can be thought of as an ecosystem, which critically means that we cannot just consider it as a collection of mutated cells but more as a complex system of many interacting…
Senescent fibroblasts can drive melanoma initiation and progression
Eunjung Kim, Vito Rebecca, Inna V. Fedorenko +6
Skin is one of the largest human organ systems whose primary purpose is the protection of deeper tissues. As such, the skin must maintain a homeostatic balance in the face of many…
A Markov chain model of evolution in asexually reproducing populations: insight and analytical tractability in the evolutionary process
Daniel Nichol, Peter Jeavons, Robert Bonomo +5
The evolutionary process has been modelled in many ways using both stochastic and deterministic models. We develop an algebraic model of evolution in a population of asexually repr…
Intrinsic cell factors that influence tumourigenicity in cancer stem cells - towards hallmarks of cancer stem cells
Jacob G. Scott, Prakash Chinnaiyan, Alexander R. A. Anderson +2
Since the discovery of a cancer initiating side population in solid tumours, studies focussing on the role of so-called cancer stem cells in cancer initiation and progression have…