602 citations · 2.2k across the 50 of their papers we have counts for
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Inferring the in vivo looping properties of DNA
Leonor Saiz, J. Miguel Rubi, Jose M. G. Vilar
The free energy of looping DNA by proteins and protein complexes determines to what extent distal DNA sites can affect each other. We inferred its in vivo value through a combined…
The mesoscopic dynamics of thermodynamic systems
D. Reguera, J. M. Rubi, J. M. G. Vilar
Concepts of everyday use like energy, heat, and temperature have acquired a precise meaning after the development of thermodynamics. Thermodynamics provides the basis for understan…
Signal processing in the TGF-beta superfamily ligand-receptor network
Jose M. G. Vilar, Ronald Jansen, Chris Sander
The TGF-beta pathway plays a central role in tissue homeostasis and morphogenesis. It transduces a variety of extracellular signals into intracellular transcriptional responses tha…
DNA looping in gene regulation: from the assembly of macromolecular complexes to the control of transcriptional noise
Jose M. G. Vilar, Leonor Saiz
The formation of DNA loops by proteins and protein complexes that bind at distal DNA sites plays a central role in many cellular processes, such as transcription, recombination, an…